The Stronger Systems for Health Security Program is a key investment of the Australian Government’s Indo-Pacific Health Security Initiative. Following a competitive peer review process, convened by the National Health and Medical Research Council, and a DFAT selection process, seven grants were selected totalling AU$16 million over 3 years. The grants involve research and capacity building activities in Indonesia, Papua New Guinea, Fiji, Timor-Leste and Vietnam to address key health security challenges. This Program will help countries in our region respond to infectious disease threats by strengthening health systems and surveillance and response mechanisms, and also invests in Australian research.