Funders: 
  • The Australian Government Department of Foreign Affairs and Trade (DFAT)
Collaborators:
  • Timor-Leste Government, Ministry of Health
  • Hospital Nacional Guido Valadares
  • National Health Laboratory

ISIN-MANA Study: Investigating Sepsis through Implementation of a Novel Microbiological and Nucleic Acid amplification testing Strategy in Timor-Leste    

Aims: 

Primary aim: 

  • Assess the feasibility of enrolling patients with acute febrile illness (AFI) into observational and/or interventional studies which may evaluate the clinical impact of novel diagnostic devices, clinical decision support systems and/or antimicrobial stewardship interventions for AFI in Timor-Leste 

Secondary aims:

  • Verify and implement a novel multiplexed PCR assay at the National Health Laboratory (NHL).
  • Describe the etiology of AFI at selected healthcare facilities in Timor-Leste.  
  • Describe the incidence and clinical features of AFI.
  • Describe the antimicrobial management and outcome of AFI 
     
Summary: 

This study will enroll patients attending healthcare facilities in Timor-Leste who have clinical features of infection and who are having a blood culture taken as part of their routine care.  A blood sample will be taken and will be tested using a multiplexed qPCR assay.  Baseline data will be collected, and participants will be actively followed-up for 10 days.  Incidence, clinical features, etiology, management, and outcome of this group of patients will be described.  Feasibility of conducting larger observational and/or interventional clinical studies on AFI within the Timor-Leste healthcare system will be assessed.

Chief Investigator:
  • Gustodio de Jesus Alves, Emergency physician and clinical educator, Hospital Nacional Guido Valadares (HNGV) 
Project Manager: 
  • Salvador Amaral 
Contact information:
Project dates: 
  • September 2022 - September 2023