Study title:
Effectiveness of novel approaches to radical cure with tafenoquine and primaquine (EFFORT).
Objectives:
Primary:
- To assess the effectiveness of a short-course of high dose primaquine (total dose 7mg/kg given unsupervised over 7 days) compared to the current standard low dose primaquine regimen (total dose 3.5mg/kg given unsupervised over 14 days).
Secondary:
- To assess the effectiveness of tafenoquine (single dose of 300mg) compared to the short-course high dose primaquine regimen.
- To assess the safety of tafenoquine compared to the high and low dose primaquine regimens.
- To assess the cost-effectiveness and feasibility of high dose primaquine and tafenoquine compared to the current low dose primaquine regimen.
Chief investigator:
Project manager:
Other investigators:
- Dr Benedikt Ley, Menzies School of Health Research
- Professor Ric Price - Menzies School of Health Research
Project dates:
The trial has commenced.
For further information, please email.